1-Methylpiperazine → HCID 178480672, compound

HRID 902650Notes

Reaction equation

HRID 902650 reaction equation
Cl[C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[CH3:9][N:10]1[CH2:15][CH2:14][N:13]([C:2]2[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 1785160256-chloropyridin-2-ol

Product 1

HCID 178480672HCID 178480672, compoundYield 66%

Conditions

Temperature
90 °C

Procedure

To a stirring solution of 1-methyl-piperazine (10 ml) was added 6-chloro-2-pyridinol (1.5 g, 11.57 mmol) and the mixture was heated at 90° C. for 60 h. The reaction mixture was cooled to RT and concentrated under reduced pressure (while heating) to afford the title compound as a brown solid (66%). The crude material was used without further purification. MS (ESI) 194.2 (M+H+).

Workup

  1. temperatureThe reaction mixture was cooled to RT
  2. concentrationconcentrated under reduced pressure (while heating)

Sources & evidence

ORD record
ord-6a0c3e8b61c94e06bbf0cae4be762cc4
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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