反应详情

A solution of [3-(3-bromo-propoxy)-phenyl]-acetic acid methyl ester (1.5 g, 5.26 mmol) and 2-chloro-3-trifluoromethyl-benzylamine (1 g, 4.77 mmol) in acetonitrile (300 ml) was treated with solid potassium carbonate (0.79 g, 5.74 mmol). The reaction was heated to reflux and stirred overnight. Upon cooling to room temperature, the reaction was filtered through a pad of celite, washed with EtOAc, and the filtrate was concentrated in vacuo. The crude product was purified by column chromatograph (EtOAc:Hexane/30:90) to give the title compound as an oil (1.5 g, 50%). MS m/e 402.2 (M+H)+.

1. temperatureThe reaction was heated
2. temperatureto reflux
3. filtrationthe reaction was filtered through a pad of celite
4. washwashed with EtOAc
5. concentrationthe filtrate was concentrated in vacuo
6. customThe crude product was purified by column chromatograph (EtOAc:Hexane/30:90)