反应详情

A solution of methyl 2,2-dimethyl-3-(3-benzyloxyphenyl)propionate (208 mg, 0.7 mmole) in 10 mL of MeOH and 1 mL of 1N HCl was treated with 10% Pd/C (100 mg) and hydrogenated on a Parr shaker with 50 psi H2 pressure for 1 hour. The catalyst was filtered, and the filtrate was concentrated, diluted with H2O and extracted with Et2O. The extracts were washed with H2O, dried and the solvent removed, and gave the titled product, 140 mg (97% yield). MS (ESI) 209 (MH+).

1. filtrationThe catalyst was filtered
2. concentrationthe filtrate was concentrated
3. additiondiluted with H2O
4. extractionextracted with Et2O
5. washThe extracts were washed with H2O
6. customdried
7. customthe solvent removed