2-(3-Chlorophenyl)propanoic acid → N-(3-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide

HRID 902727Notes

Reaction equation

HRID 902727 reaction equation
[Cl:1]C1C=C(C(C)C(O)=O)C=CC=1.Cl[C:14]1[C:32]([C:33]([F:36])([F:35])[F:34])=[CH:31][CH:30]=[CH:29][C:15]=1[CH2:16][NH:17][C:18](=[O:28])[CH:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[Cl:27])[CH3:20]>>[Cl:1][C:32]1([C:33]([F:36])([F:35])[F:34])[CH:31]=[CH:30][CH:29]=[C:15]([CH2:16][NH:17][C:18](=[O:28])[CH:19]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[Cl:27])[CH3:20])[CH2:14]1

Participants

3

Reactant 2

HCID 131095352-(3-Chlorophenyl)propanoic acidHCID 69254638N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide

Product 1

HCID 69254690N-(3-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamideYield 22%

Procedure

The titled compound was prepared from 2-(3-Chlorophenyl)propionic acid in 22% yield in the same manner as the preparation of N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide in Example 184b. MS (ESI) 376 (MH+).

Sources & evidence

ORD record
ord-209dd69bdce4436ab76c348c29497422
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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