Propionic Acid → N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamide

HRID 902736Notes

Reaction equation

HRID 902736 reaction equation
[C:1](O)(=[O:4])CC.[Cl:6][C:7]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:8]=1[CH2:9][NH:10][C:11](=[O:21])[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1Cl)[CH3:13]>>[Cl:6][C:7]1[C:25]([C:26]([F:29])([F:28])[F:27])=[CH:24][CH:23]=[CH:22][C:8]=1[CH2:9][NH:10][C:11](=[O:21])[CH:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:4][CH3:1])[CH3:13]

Participants

3

Reactant 2

HCID 1032Propionic AcidHCID 69254638N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide

Product 1

HCID 69251127N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamideYield 42%

Procedure

The titled compound was prepared from 22-methoxyphenyl)propionic acid in 42% yield in the same manner as the preparation of N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propionamide in Example 184b. MS (ESI) 372 (MH+).

Sources & evidence

ORD record
ord-0975714eff3246cfbe4c077f790f32f4
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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