N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamide → N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propylamine

HRID 902737Notes

Reaction equation

HRID 902737 reaction equation
[Cl:1][C:2]1[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][NH:5][C:6](=O)[CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16])[CH3:8].ClC1C(C(F)(F)F)=CC=CC=1CNCC(C1C=CC=CC=1Cl)C>>[Cl:1][C:2]1[C:21]([C:22]([F:23])([F:24])[F:25])=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][NH:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16])[CH3:8]

Participants

3

Reactant 2

HCID 69251127N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamideHCID 69252183N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine

Product 1

HCID 69253869N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propylamineYield 28%

Procedure

The titled compound was prepared from N-(2-chloro-3-trifluoromethylbenzyl)-2-(2-methoxyphenyl)propionamide in 28% yield in the same manner as the preparation of N-(2-chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine in Example 184c. MS (ESI) 358 (MH+).

Sources & evidence

ORD record
ord-a4d8ed50645d4413a7c2468ef2ec3066
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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