2-Phenylhexan-1-amine → N-(2-Phenylhexyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

HRID 902753Notes

Reaction equation

HRID 902753 reaction equation
[C:1]1(C(CCCC)CN)[CH:6]=CC=C[CH:2]=1.Cl.[C:15]1([CH:21]([CH2:50]C(C)C)[CH2:22][N:23]([CH2:36][CH2:37][CH2:38][O:39][C:40]2[CH2:41][C:42](=[CH:46][C:47]([OH:49])=[O:48])[CH:43]=[CH:44][CH:45]=2)[CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[C:26]=2[Cl:35])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[ClH:35].[C:15]1([CH:21]([CH2:50][CH2:2][CH2:1][CH3:6])[CH2:22][N:23]([CH2:36][CH2:37][CH2:38][O:39][C:40]2[CH2:41][C:42](=[CH:46][C:47]([OH:49])=[O:48])[CH:43]=[CH:44][CH:45]=2)[CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([C:31]([F:33])([F:34])[F:32])[C:26]=2[Cl:35])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 446932-Phenylhexan-1-amineHCID 131726851N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

Product 1

HCID 131726853N-(2-Phenylhexyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

Procedure

The titled compound was prepared from 2-phenylhexylamine (J. Chem. Soc. Perk. Trans. 1: Organic and Biorganic Chemistry (1976), (1), 33-8) in the same manner as the preparation of N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride, Example 189e-h. MS (ESI) 562 (MH+)

Sources & evidence

ORD record
ord-f38f6f00f49745b8bdff7e5068bce182
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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