HRID902754

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID54435858

未命名化合物

反应SMILES：CC(C)CC(CN(CCCOC1=CC=CC(=CC(=O)O)C1)Cc1cccc(C(F)(F)F)c1Cl)c1ccccc1.Cl

HCID131726851

未命名化合物

PRODUCTS

产物

反应SMILES：C#CC(CN(CCCOC1=CC=CC(=CC(=O)O)C1)Cc1cccc(C(F)(F)F)c1Cl)c1ccccc1

HCID86598298

未命名化合物

PROCEDURE

实验过程

The titled compound was prepared from 2-ethynylphenethylamine (J. Med. Chem. (1988), 31(4), 704-6) in the same manner as the preparation of N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride, Example 189e-h. MS (ESI) 530 (MH+)

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-8965c070e44e46a9ac0baa539f903731
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07365085B2
来源说明: uspto-grants-2008_04

反应SMILES

C(C1C=CC=CC=1CCN)#C.Cl.[C:13]1([CH:19]([CH2:48][CH:49](C)C)[CH2:20][N:21]([CH2:34][CH2:35][CH2:36][O:37][C:38]2[CH2:39][C:40](=[CH:44][C:45]([OH:47])=[O:46])[CH:41]=[CH:42][CH:43]=2)[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:32])([F:31])[F:30])[C:24]=2[Cl:33])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([CH:19]([C:48]#[CH:49])[CH2:20][N:21]([CH2:34][CH2:35][CH2:36][O:37][C:38]2[CH2:39][C:40](=[CH:44][C:45]([OH:47])=[O:46])[CH:41]=[CH:42][CH:43]=2)[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([F:30])([F:32])[F:31])[C:24]=2[Cl:33])[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1