HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Ethynylphenyl)ethan-1-amine → N-(2-Phenyl-3-butynyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Ethynylphenyl)ethan-1-amine | HCID 54435858 | — |
| Reactant | N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride | HCID 131726851 | — |
| Product | N-(2-Phenyl-3-butynyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine | HCID 86598298 | — |
Reaction Steps
The titled compound was prepared from 2-ethynylphenethylamine (J. Med. Chem. (1988), 31(4), 704-6) in the same manner as the preparation of N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride, Example 189e-h. MS (ESI) 530 (MH+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365085B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-8965c070e44e46a9ac0baa539f903731 |
| Source note | uspto-grants-2008_04 |