反应详情

An aqueous solution of HCl (36%, 68 mL) was added to a solution of methyl 2-(chloromethyl)-1,3-thiazole-4-carboxylate (34 g, 177 mmol) in dioxane (680 mL), water (65 mL) and refluxed overnight. The dioxane was then removed in vacuo and the product was extracted from the aqueous layer with MTBE (4×473 mL), dried over MgSO4 and evaporated to give the title compound (28.3 g, 97%).

1. temperaturerefluxed overnight
2. customThe dioxane was then removed in vacuo
3. extractionthe product was extracted from the aqueous layer with MTBE (4×473 mL)
4. dry with materialdried over MgSO4
5. customevaporated