HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate → 4-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate | HCID 45156786 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoic acid | HCID 16777305 | 78.8% |
Reaction Steps
An aqueous solution of HCl (6N, 200 mL) was added to methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate (20.0 g, 0.075 mol) and refluxed overnight. The reaction mixture was allowed to cool to ambient temperatures and the solid was filtered and then dried in vacuo at 40° C. to give the title compound (15.0 g, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365225B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-838eed514c4e41c08fac337aa0623775 |
| Source note | uspto-grants-2008_04 |