反应详情

An aqueous solution of HCl (6N, 200 mL) was added to methyl 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoate (20.0 g, 0.075 mol) and refluxed overnight. The reaction mixture was allowed to cool to ambient temperatures and the solid was filtered and then dried in vacuo at 40° C. to give the title compound (15.0 g, 75%).

1. temperaturerefluxed overnight
2. temperatureto cool to ambient temperatures
3. filtrationthe solid was filtered
4. customdried in vacuo at 40° C.