Water → HCID 57432610, compound

HRID 902863Notes

Reaction equation

HRID 902863 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.C(N(CC)CC)C.Cl[C:17](=[O:22])[C:18]([O:20][CH3:21])=[O:19].O>N1C=CC=CC=1>[Cl:8][C:5]1[N:4]=[N:3][C:2]([NH:1][C:17](=[O:22])[C:18]([O:20][CH3:21])=[O:19])=[CH:7][CH:6]=1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 216436-Amino-3-chloropyridazineHCID 79846Methyl chloroglyoxylate

Product 1

HCID 57432610HCID 57432610, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Amino-6-chloropyridazine (516 mg) was dissolved in pyridine (26 ml), and triethylamine (665 μl) and methyl chlorooxoacetate (441 μl) were successively added under ice cooling to stir the mixture at room temperature for 14 hours. After water was added to the reaction mixture to conduct liquid separation, the resultant organic layer was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (748 mg).

Workup

  1. customliquid separation
  2. dry with materialthe resultant organic layer was dried over anhydrous sodium sulfate
  3. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-d8437f93416e4a7ab8bf214f01b3ab05
Source dataset
uspto-grants-2008_04
Patent number
US07365205B2

Reaction notes

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