反应详情

温度

60 °C

4-Chloroaniline (2.0 g) was dissolved in acetonitrile (20 ml), and ethyl bromoacetate (2.1 g) and potassium carbonate (2.2 g) were added to stir the mixture at 60° C. for 2 days. The reaction mixture was filtered through Celite pad, and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1) to obtain the title compound (2.3 g).

1. filtrationThe reaction mixture was filtered through Celite pad
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1)