Potassium Carbonate → HCID 87735051, compound

To a stirring solution of the crude compound of example 24 (6.87 g; 26.19 mmoles) in degassed methanol (270 mL) at room temperature was added drop wise a 10% aqueous solution of potassium carbonate (7.24 g; 52.38 mmoles). The mixture was stirred for three hours at room temperature. After complete consumption of the starting material (as confirmed by TLC: 30% ethyl acetate-70% hexanes), the reaction mixture was poured into degassed water (500 mL) and was extracted with degassed dichloromethane (2×200 mL) and then was acidified with a 10% aqueous hydrochloric acid solution. The aqueous layer was finally extracted with ethyl acetate (4×500 mL). The organic extracts were combined, dried (anhydrous MgSO4), filtered and evaporated to yield 8.10 g of the crude desired compound. This residue was used directly in the next step without any further purification.

1. customAfter complete consumption of the starting material (as confirmed by TLC: 30% ethyl acetate-70% hexanes)
2. additionthe reaction mixture was poured
3. custominto degassed water (500 mL)
4. extractionwas extracted with degassed dichloromethane (2×200 mL)
5. extractionThe aqueous layer was finally extracted with ethyl acetate (4×500 mL)
6. dry with materialdried (anhydrous MgSO4)
7. filtrationfiltered
8. customevaporated

ORD record

ord-debf59bf88d14f2e96f86e1f6dd085a8

Source dataset

uspto-grants-2008_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07365091B2