Tryptamine → HCID 10094730, compound

HRID 902942Notes

Reaction equation

HRID 902942 reaction equation
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.C([O:17][C:18](=[O:55])[CH2:19][CH:20]([NH:24][C:25](=[O:54])[CH:26]([S:34]C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:21](O)=[O:22])(C)(C)C>>[NH:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][NH:1][C:21](=[O:22])[CH:20]([NH:24][C:25](=[O:54])[CH:26]([SH:34])[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:19][C:18]([OH:55])=[O:17])=[CH:5]1

Participants

3

Reactant 2

HCID 1150TryptamineHCID 69211665HCID 69211665, compound

Product 1

HCID 10094730HCID 10094730, compoundYield 39%

Procedure

This compound was prepared by condensing tryptamine with 2-(3-phenyl-2-tritylsulfanyl-propionylamino)-succinic acid 4-tert-butyl ester using the same coupling conditions as previously described. Deprotection and purification then provided the title compound (39%): (Pos FAB) 440 (MH+).

Workup

  1. customDeprotection and purification

Sources & evidence

ORD record
ord-e0f9893762a94228957cfcbdc4303230
Source dataset
uspto-grants-2008_04
Patent number
US07365091B2

Reaction notes

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