反应详情

10.1 g of triethyamine was added to the solution of 1C, then 13.6 g of N-methoxy-N-methylcarbamoyl chloride was added drop-by-drop. After 12 hours at room temperature, the mixture was washed with water and extracted with ether. The extract was dried and the ether was evaporated under reduced pressure. The residue was chromatographed over silica gel to give 1, as a white solid, mp: 151°-153° C.

1. washthe mixture was washed with water
2. extractionextracted with ether
3. customThe extract was dried
4. customthe ether was evaporated under reduced pressure
5. customThe residue was chromatographed over silica gel
6. customto give 1