Potassium Hydroxide → HCID 23337314, compound

HRID 903002Notes

Reaction equation

HRID 903002 reaction equation
[OH-].[K+].[Cl:3][C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[NH:13][C:14](=[O:20])[O:15][CH:16]([CH3:19])[CH2:17]Cl>O.CO>[Cl:3][C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[N:13]1[CH2:17][CH:16]([CH3:19])[O:15][C:14]1=[O:20]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 54209620HCID 54209620, compound

Product 1

HCID 23337314HCID 23337314, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 5 g of potassium hydroxide in 10 ml of water was added to a stirred solution of 21.5 g of 2A in 300 ml of methanol. The mixture was heated for 0.5 hour by a steam bath and concentrated to dryness under reduced pressure. The residue was diluted with water; the mixture was acidified with hydrochloric acid and extracted with ether. The extract was dried and the solvent was evaporated under reduced pressure. Trituration of the residue with hexane gave 3-(2-chloro-4-nitrophenyl)-5-methyl-2-oxazolidinone (2B), as a solid, mp: 73°-75° C.

Workup

  1. temperatureThe mixture was heated for 0.5 hour by a steam bath
  2. concentrationconcentrated to dryness under reduced pressure
  3. additionThe residue was diluted with water
  4. extractionextracted with ether
  5. customThe extract was dried
  6. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-57826d71b0ff4fecab0f5d0b4368a350
Source dataset
uspto-grants-1980_10
Patent number
US04226612

Reaction notes

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