Potassium Hydroxide → HCID 23337314, compound

Participants

Reaction Steps

A solution of 5 g of potassium hydroxide in 10 ml of water was added to a stirred solution of 21.5 g of 2A in 300 ml of methanol. The mixture was heated for 0.5 hour by a steam bath and concentrated to dryness under reduced pressure. The residue was diluted with water; the mixture was acidified with hydrochloric acid and extracted with ether. The extract was dried and the solvent was evaporated under reduced pressure. Trituration of the residue with hexane gave 3-(2-chloro-4-nitrophenyl)-5-methyl-2-oxazolidinone (2B), as a solid, mp: 73°-75° C.

Provenance & Evidence