反应详情

2-Methyl-3-keto-butyronitrile (J. Am. Chem. Soc. 79, 723, 1957) (25.25 g.) in 120 ml. ethanol was treated with 15 g. methylhydrazine while cooling. The solution was refluxed 3 hours then concentrated in vacuum, benzene added and the solution concentrated again. Ether was added to give 29.12 g. mp 70-106 of base (contained H2O). This was converted to the hydrochloride with HCl in isopropyl alcohol. HCl had mp 286-288.

1. temperatureThe solution was refluxed 3 hours
2. concentrationthen concentrated in vacuum, benzene
3. additionadded
4. concentrationthe solution concentrated again
5. additionEther was added
6. customto give 29.12 g