Acetate → Flurbiprofen

HRID 903109Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 903109
[Tl].C([O-])(=O)C.[F:6][C:7]1[CH:12]=[C:11]([CH:13]([CH3:18])[C:14]([O:16]C)=[O:15])[CH:10]=[CH:9][C:8]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C(O)(=O)C.CCCCCC>[F:6][C:7]1[CH:12]=[C:11]([CH:13]([CH3:18])[C:14]([OH:16])=[O:15])[CH:10]=[CH:9][C:8]=1[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Komponenten

5

Edukt 3

HCID 175AcetateHCID 4127Flurbiprofen Methyl EsterHCID 5359464Thallium

Produkt 1

HCID 3394Flurbiprofen

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22590778Acetic Acid HexaneLösungsmittel

Versuchsvorschrift

Following the procedure of Example 2, the enol ether of the formula ##STR2## is reacted with thallium (lll) acetate in an aqueous acetic acid/hexane mixture at 25° to 50° C. until methyl 2-(2-fluoro-4-biphenylyl)propionate is formed. This ester is isolated from the reaction mixture and hydrolyzed to 2-(2-fluoro-4-biphenylyl)propionic acid (generic name, flurbiprofen) by the described procedure.

Aufarbeitung

  1. customis formed

Quellen und Nachweise

ORD-Eintrag
ord-e69669eaae284500911b8cdc59cc1fe4
Quelldatensatz
uspto-grants-1980_10
Patentnummer
US04226790

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