HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetate → Flurbiprofen
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetate | HCID 175 | — |
| Reactant | Flurbiprofen Methyl Ester | HCID 4127 | — |
| Reactant | Thallium | HCID 5359464 | — |
| Solvent | Acetic Acid Hexane | HCID 22590778 | — |
| Product | Flurbiprofen | HCID 3394 | — |
Reaction Steps
Following the procedure of Example 2, the enol ether of the formula ##STR2## is reacted with thallium (lll) acetate in an aqueous acetic acid/hexane mixture at 25° to 50° C. until methyl 2-(2-fluoro-4-biphenylyl)propionate is formed. This ester is isolated from the reaction mixture and hydrolyzed to 2-(2-fluoro-4-biphenylyl)propionic acid (generic name, flurbiprofen) by the described procedure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226790 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-e69669eaae284500911b8cdc59cc1fe4 |
| Source note | uspto-grants-1980_10 |