Methyl Isocyanate → HCID 13420165, compound

HRID 903130Notes

Reaction equation

HRID 903130 reaction equation
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]([NH2:10])=[O:9])[CH2:2]1.[CH3:15][N:16]=[C:17]=[O:18]>C1C=CC=CC=1>[CH3:15][NH:16][C:17]([N:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8]([NH2:10])=[O:9])[CH2:2]1)=[O:18]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 12812503HCID 12812503, compound

Product 1

HCID 13420165HCID 13420165, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To 8.0 g. (0.028 mole) of 2-(3-azetidinyloxy)benzamide stirring in 100 ml of dry benzene was added dropwise 1.6 g. (0.028 mole) of methylisocyanate with ice bath cooling. Stirring was continued at room temperature for 24 hours. The solid material was filtered and was recrystallized from 95% ethanol. The product (4.0 g., 57%) melted at 236°-240° C.

Workup

  1. filtrationThe solid material was filtered
  2. customwas recrystallized from 95% ethanol

Sources & evidence

ORD record
ord-6d0056a1cc0b48f8a42b21a73091dcc3
Source dataset
uspto-grants-1980_10
Patent number
US04226861

Reaction notes

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