Methyl Isocyanate → HCID 13420169, compound

HRID 903135Notes

Reaction equation

HRID 903135 reaction equation
[NH:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:14]=[CH:13][C:9]([C:10]([NH2:12])=[O:11])=[CH:8][CH:7]=2)[CH2:2]1.[CH3:15][N:16]=[C:17]=[O:18]>C1C=CC=CC=1>[CH3:15][NH:16][C:17]([N:1]1[CH2:4][CH:3]([O:5][C:6]2[CH:7]=[CH:8][C:9]([C:10]([NH2:12])=[O:11])=[CH:13][CH:14]=2)[CH2:2]1)=[O:18]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 12812508HCID 12812508, compound

Product 1

HCID 13420169HCID 13420169, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a stirring solution of 5.0 g. (0.026 mole) of 4-(3-azetidinyloxy)benzamide in 75 ml. of dry benzene was added dropwise 1.5 g. (0.026 mole) of methylisocyanate. Stirring was continued for 1.5 hours. The white solid which separated was filtered and recrystallized using 95% ethanol. The solid was triturated with acetonitrile (due to solvation effects of the ethanol). The product weighed 4.0 g. (58%) and melted at 208°-210° C.

Workup

  1. customThe white solid which separated
  2. filtrationwas filtered
  3. customrecrystallized
  4. customThe solid was triturated with acetonitrile (due to solvation effects of the ethanol)

Sources & evidence

ORD record
ord-d3f759400d0e442297e2589dfef03523
Source dataset
uspto-grants-1980_10
Patent number
US04226861

Reaction notes

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