反应详情

The cyanohydrin of Example 4 (6.0 g, 34.7 mmol) was dissolved in 60 ml ethanol and perfused with hydrogen chloride for 30 minutes. After a 16 hour reaction period at 0° C. the mixture was evaporated in vacuo to a solid which was triturated with ether. The residue was taken up in 200 ml chloroform and washed with 2×50 ml saturated sodium bicarbonate, 1×50 ml brine, dried over sodium sulfate, filtered, and concentrated to a solid; 5.3 g (71%), mp 84°-86° C.

1. customAfter a 16 hour reaction period at 0° C. the mixture
2. customwas evaporated in vacuo to a solid which
3. customwas triturated with ether
4. washwashed with 2×50 ml saturated sodium bicarbonate, 1×50 ml brine
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated to a solid