2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid → HCID 15313948, compound

HRID 903170Notes

Reaction equation

HRID 903170 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:34]([CH3:36])[CH3:35])[C:14]([O:16][CH:17](C#N)C1C=CC=C(OC2C=CC(F)=CC=2)N=1)=[O:15].ClC1C=C(C(F)(F)F)C=CC=1NC(C(C)C)C(OC(C#N)C1C=CC=C(OC2C=CC(C)=CC=2)N=1)=O.ClC1C=C(C(F)(F)F)C=CC=1NC(C(C)C)C(OC(C#N)C1C=CC=C(OC2C=CC(OC)=CC=2)N=1)=O.ClC1C=C(C(F)(F)F)C=CC=1NC(C(C)C)C(OC(C#N)C1C=CC=C(OC2C=CC(Cl)=CC=2)N=1)=O.ClC1C=C(C(F)(F)F)C=CC=1NC(C(C)C)C(OC(C#N)C1C=CC=C(OC2SC=CC=2C)N=1)=O.ClC1C=C(C(F)(F)F)C=CC=1NC(C(C)C)C(O)=O.C(C(C1C=CC=C(OC2C=CC(F)=CC=2)N=1)O)#N.C(C(C1C=CC=C(OC2C=CC(C)=CC=2)N=1)O)#N.C(C(C1C=CC=C(OC2C=CC(OC)=CC=2)N=1)O)#N.C(C(C1C=CC=C(OC2C=CC(Cl)=CC=2)N=1)O)#N.C(C(C1C=CC=C(SC2C=CC(C)=CC=2)N=1)O)#N.C(C(C1C=CC=C(OC2C=CC(C(F)(F)F)=CC=2)N=1)O)#N>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:34]([CH3:36])[CH3:35])[C:14]([O:16][CH3:17])=[O:15]

Participants

13

Reactant 12

HCID 39476432-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acidHCID 20285866HCID 20285866, compoundHCID 20293447Cyano[6-(4-fluorophenoxy)-2-pyridyl]methanolHCID 23337856HCID 23337856, compoundHCID 23337863HCID 23337863, compoundHCID 23470896HCID 23470896, compoundHCID 54317032HCID 54317032, compoundHCID 54355766HCID 54355766, compoundHCID 54357152HCID 54357152, compoundHCID 54530615Cyano[6-(4-methylphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoateHCID 70593611HCID 70593611, compoundHCID 131711911HCID 131711911, compound

Product 1

HCID 15313948HCID 15313948, compound

Procedure

By the above procedure, each of cyano[6-(4-fluorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(4-methylphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(4-methoxyphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(4-chlorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(methylthiophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, and cyano[6-(4-trifluoromethylphenoxy)-2-pyridyl)]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate is prepared by the reaction of the acid chloride of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid with each of cyano[6-(4-fluorophenoxy)-2-pyridyl]methanol, cyano[6-(4-methylphenoxy)-2-pyridyl]methanol, cyano[6-(4-methoxyphenoxy)-2-pyridyl]methanol, cyano[6-(4-chlorophenoxy)-2-pyridyl]methanol, cyano[6-(4-methylthiophenoxy)-2-pyridyl]methanol and cyano[6-(4-trifluoromethylphenoxy)-2-pyridyl]methanol, respectively.

Sources & evidence

ORD record
ord-a98f46b544d64e29ba4b07d6c50df1af
Source dataset
uspto-grants-1980_10
Patent number
US04226872

Reaction notes

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