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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 903170Generated: October 31, 2026

2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid → HCID 15313948, compound

https://huagongshe.com/reaction/903170

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acidHCID 3947643—
ReactantHCID 20285866HCID 20285866—
ReactantCyano[6-(4-fluorophenoxy)-2-pyridyl]methanolHCID 20293447—
ReactantHCID 23337856HCID 23337856—
ReactantHCID 23337863HCID 23337863—
ReactantHCID 23470896HCID 23470896—
ReactantHCID 54317032HCID 54317032—
ReactantHCID 54355766HCID 54355766—
ReactantHCID 54357152HCID 54357152—
ReactantCyano[6-(4-methylphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoateHCID 54530615—
ReactantHCID 70593611HCID 70593611—
ReactantHCID 131711911HCID 131711911—
ProductHCID 15313948HCID 15313948—

Reaction Steps

By the above procedure, each of cyano[6-(4-fluorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(4-methylphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(4-methoxyphenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(4-chlorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, cyano[6-(methylthiophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate, and cyano[6-(4-trifluoromethylphenoxy)-2-pyridyl)]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate is prepared by the reaction of the acid chloride of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid with each of cyano[6-(4-fluorophenoxy)-2-pyridyl]methanol, cyano[6-(4-methylphenoxy)-2-pyridyl]methanol, cyano[6-(4-methoxyphenoxy)-2-pyridyl]methanol, cyano[6-(4-chlorophenoxy)-2-pyridyl]methanol, cyano[6-(4-methylthiophenoxy)-2-pyridyl]methanol and cyano[6-(4-trifluoromethylphenoxy)-2-pyridyl]methanol, respectively.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04226872
Source datasetuspto-grants-1980_10
ORD IDord-a98f46b544d64e29ba4b07d6c50df1af
Source noteuspto-grants-1980_10