2-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acid → [6-(4-Fluorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate

HRID 903171Notes

Reaction equation

HRID 903171 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([OH:16])=[O:15].[F:20][C:21]1[CH:35]=[CH:34][C:24]([O:25][C:26]2[N:31]=[C:30]([CH2:32]O)[CH:29]=[CH:28][CH:27]=2)=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH:13]([CH:17]([CH3:19])[CH3:18])[C:14]([O:16][CH2:32][C:30]1[CH:29]=[CH:28][CH:27]=[C:26]([O:25][C:24]2[CH:34]=[CH:35][C:21]([F:20])=[CH:22][CH:23]=2)[N:31]=1)=[O:15]

Participants

3

Reactant 2

HCID 39476432-{[2-Chloro-4-(trifluoromethyl)phenyl]amino}-3-methylbutanoic acidHCID 20285867[6-(4-Fluorophenoxy)-2-pyridyl]methanol

Product 1

HCID 23337845[6-(4-Fluorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate

Procedure

The acid chloride of 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid is reacted with [6-(4-fluorophenoxy)-2-pyridyl]methanol using the procedure of Example 1 to give [6-(4-fluorophenoxy)-2-pyridyl]methyl 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoate.

Sources & evidence

ORD record
ord-176fb71ae6a44f11ade06e353acc5fb2
Source dataset
uspto-grants-1980_10
Patent number
US04226872

Reaction notes

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