反应详情

The 6-benzoyl-2-methylpyridine (3.9 g, 21 mmol), in 20 ml CHCl3, is added over 1 hour to 4.2 g (21 mmol) m-chloroperbenzoic acid (in 50 ml CHCl3). The temperature is kept below 25° as the mixture is stirred overnight. The reaction is diluted with CHCl3, washed with sat. NaHSO3, water, 20% NaHCO3 (2×) and then water, dried, stripped and finally titrated with hexane/ethyl acetate to give 6-benzoyl-2-methylpyridine N-oxide.

1. customis kept below 25° as the mixture
2. washwashed with sat. NaHSO3, water, 20% NaHCO3 (2×)
3. dry with materialwater, dried