反应详情

A solution of 3.3 g of aminoguanidine sulphate in 30 ml. of water is added to a solution of 2.8 g. of o-chlorophenoxy acetaldehyde in 30 ml. of ethyl alcohol at 95°. Heating is effected under reflux for 4 hours, with addition of a few drops of acetic acid. After cooling, a solid product precipitates and it is separated and washed with very little water followed by ethanol. Recrystallisation is effected in the water-ethanol mixture (1/1). The o-chlorophenoxy acetaldehyde guanyl hydrazone is obtained in the form of sulphate, m.p.=198° C., with a yield of 90%.

1. customat 95°
2. temperatureHeating
3. temperatureAfter cooling
4. customa solid product precipitates
5. customit is separated
6. washwashed with very little water
7. customRecrystallisation