Water → HCID 22165505, compound

HRID 903192Notes

Reaction equation

HRID 903192 reaction equation
[C:1]([O:4][CH2:5][C:6](=[O:9])[CH2:7][OH:8])(=[O:3])[CH3:2].[O-:10][C:11]#[N:12].[Na+].FC(F)(F)C(O)=O.O>C1C=CC=CC=1>[C:1]([O:4][CH2:5][C:6](=[O:9])[CH2:7][O:8][C:11](=[O:10])[NH2:12])(=[O:3])[CH3:2]

Participants

6

Reactant 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 517096Sodium CyanateHCID 18702505HCID 18702505, compound

Product 1

HCID 22165505HCID 22165505, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a stirred mixture of 1-acetoxy-3-hydroxy-2-propanone (10.8 g., 0.1 mole) and sodium cyanate (13.0 g., 0.2 mole) in benzene (50 ml.) is slowly added trifluoroacetic acid (15.5 ml., 0.21 mole). The reaction mixture is stirred for three hours, then water (15 ml.) is added. The organic layer is separated, dried and the solvent removed under reduced pressure to afford 1-acetoxy-3-carbamoyloxy-2-propanone.

Workup

  1. customThe organic layer is separated
  2. customdried
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-59b39a7b62f747eb9c2029b94e33305a
Source dataset
uspto-grants-1980_10
Patent number
US04226866

Reaction notes

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