Benzoyl isothiocyanate → N-benzoyl-N'-[3-(2-benzimidazolylamino)propyl]thiourea

HRID 903282Notes

Reaction equation

HRID 903282 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[NH:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.[C:15]([N:23]=[C:24]=[S:25])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:15]([NH:23][C:24]([NH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[N:7]=1)=[S:25])(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 11593576N1-(1H-benzo[d]imidazol-2-yl)propane-1,3-diamine

Product 1

HCID 54012460N-benzoyl-N'-[3-(2-benzimidazolylamino)propyl]thiourea

Procedure

Reacting 2-(3-aminopropylamino)benzimidazole with benzoyl isothiocyanate by the procedure of Example 46 gives N-benzoyl-N'-[3-(2-benzimidazolylamino)propyl]thiourea.

Sources & evidence

ORD record
ord-73faa2c8a1414df5a6cd9cc3ab51f0ed
Source dataset
uspto-grants-1980_10
Patent number
US04226874

Reaction notes

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