Sodium Bicarbonate → Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

HRID 903312Notes

Reaction equation

HRID 903312 reaction equation
[CH:1]1([CH3:13])[CH2:6][CH2:5][CH:4]([CH:7]([CH3:9])[CH3:8])[CH:3]([C:10](Cl)=[O:11])[CH2:2]1.Cl.[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH2:21])[CH2:16][CH3:17].C(=O)(O)[O-].[Na+]>>[CH2:15]([O:18][C:19](=[O:22])[CH2:20][NH:21][C:10]([CH:3]1[CH:4]([CH:7]([CH3:9])[CH3:8])[CH2:5][CH2:6][CH:1]([CH3:13])[CH2:2]1)=[O:11])[CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 516892Sodium BicarbonateHCID 2759254Propyl aminoacetate hydrochlorideHCID 13734319Cyclohexanecarbonyl chloride, 5-methyl-2-(1-methylethyl)-

Product 1

HCID 56843152Propyl N-((5-methyl-2-(isopropyl)cyclohexyl)carbonyl)glycinate

Procedure

Following the procedure of Example 2 p-menth-3-oyl chloride (2.0 g., 0.01 moles), was reacted with glycine propyl ester hydrochloride (1.5 g., 0.01 moles) and sodium bicarbonate (1.6 g., 0.02 moles). The crude product was distilled b.p. 170°/0.1 mm. (After distillation the product rapidly solidifies). (Found, C: 68.2; H: 1016; N: 5.0. C16H29NO3 requires, C: 67.8; H: 10.6; N: 4.9.)

Workup

  1. distillationThe crude product was distilled b.p. 170°/0.1 mm
  2. distillation(After distillation the product

Sources & evidence

ORD record
ord-f2835db3e16c4f8a885b5fbe51150938
Source dataset
uspto-grants-1980_10
Patent number
US04226988

Reaction notes

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