反应详情

N,N-Dimethylguanidine hydrochloride (3.23g; 0.026 mol.) was added to a solution of sodium (0.61 g; 0.026 mol.) in anhydrous ethanol (50 ml.) and the mixture was heated under reflux for 30 minutes. The carbamate prepared in (a) above (5.0 g., 0.026 mol.) was then added and the mixture heated under reflux for 22 hours. The ethanol was removed, water (75 ml.) added, and the pH of the solution adjusted to 6 to 7 with acetic acid. The product was collected, washed with water, and recrystallised from ethanol to give 4-dimethylamino-6-ethoxy-1,3,5-triazin-2-one.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 30 minutes
3. additionwas then added
4. temperaturethe mixture heated
5. temperatureunder reflux for 22 hours
6. customThe ethanol was removed
7. additionwater (75 ml.) added
8. customThe product was collected
9. washwashed with water
10. customrecrystallised from ethanol