Sulfuric Acid → HCID 23338214, compound

HRID 903337Notes

Reaction equation

HRID 903337 reaction equation
[CH2:1]([C:3]1([CH2:10][CH3:11])[NH:7][C:6](=[O:8])[NH:5][C:4]1=[O:9])[CH3:2].[Cl-].[Li+].[CH2:14]1[O:17][CH:15]1[CH3:16].S(=O)(=O)(O)O>CN(C)C=O>[OH:17][CH:15]([CH3:14])[CH2:16][N:7]1[C:3]([CH2:1][CH3:2])([CH2:10][CH3:11])[C:4](=[O:9])[N:5]([CH2:14][CH:15]([OH:17])[CH3:16])[C:6]1=[O:8]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 6378Propylene OxideHCID 216005,5-DiethylhydantoinHCID 433294Lithium Chloride

Product 1

HCID 23338214HCID 23338214, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 125.0 g of 5,5-diethylhydantoin (0.8 mol), 300.0 g of dimethylformamide and 2.00 g of lithium chloride is stirred at 52° C. 128.0 g of propene oxide (2.2 mols) are added dropwise over the course of 21/2 hours. Stirring is then continued for 5 hours at 85°-90° C. The reaction mixture is adjusted to pH=7 with 2-3 drops of 25% strength sulphuric acid, and is filtered. The clear solution is concentrated on a rotational evaporator at 80° C. bath temperature, under a waterpump vacuum, and is subsequently treated under a high vacuum (0.1 mm Hg) at 80° C. until constant weight is reached.

Workup

  1. filtrationis filtered
  2. concentrationThe clear solution is concentrated on a rotational evaporator at 80° C. bath temperature
  3. additionunder a waterpump vacuum, and is subsequently treated under a high vacuum (0.1 mm Hg) at 80° C. until constant weight

Sources & evidence

ORD record
ord-4f2ebad472b146f29232f97a36f68c9a
Source dataset
uspto-grants-1980_10
Patent number
US04227005

Reaction notes

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