Ethyl 3-(6-methoxy-3-pyridyl)acrylate → Ethyl 3-(6-methoxy-3-pyridyl)propionate

HRID 903353Notes

Reaction equation

HRID 903353 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[CH:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 53930754Ethyl 3-(6-methoxy-3-pyridyl)acrylate

Product 1

HCID 12799555Ethyl 3-(6-methoxy-3-pyridyl)propionateYield 100.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl 3-(6-methoxy-3-pyridyl)acrylate (32.33 g), in ethanol (160 ml) was hydrogenated at 344 kPa at 40° using palladium-on-charcoal catalyst (5%, 0.2 g). The mixture was filtered and the filtrate was evaporated to give ethyl 3-(6-methoxy-3-pyridyl)propionate (32.7 g), as an oil.

Workup

  1. customwas hydrogenated at 344 kPa at 40°
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-c247b65dfb02443dbfc9dede9485e4e9
Source dataset
uspto-grants-1980_10
Patent number
US04227000

Reaction notes

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