5-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidone → HCID 13060036, compound

HRID 903374Notes

Reaction equation

HRID 903374 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]2[C:11](=[O:20])[NH:12][C:13]([NH:16][N+]([O-])=O)=[N:14][CH:15]=2)[CH:5]=[N:6][C:7]=1[CH3:8].[Br:21][C:22]1[C:23]([CH2:28][S:29][CH2:30][CH2:31]N)=[N:24][CH:25]=[CH:26][CH:27]=1>C(O)C>[Br:21][C:22]1[C:23]([CH2:28][S:29][CH2:30][CH2:31][NH:16][C:13]2[NH:12][C:11](=[O:20])[C:10]([CH2:9][C:4]3[CH:5]=[N:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=3)=[CH:15][N:14]=2)=[N:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 2

HCID 127838315-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidoneHCID 129515272-{[(3-Bromopyridin-2-yl)methyl]sulfanyl}ethan-1-amine

Product 1

HCID 13060036HCID 13060036, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-(5,6-dimethyl-3-pyridylmethyl)-2-nitroamino-4-pyrimidone and 1.2 molar equivalents of 2-(3-bromo-2-pyridylmethylthio)ethylamine was heated under reflux in ethanol for 48 hours, evaporated to dryness and the product isolated as 2-[2-(3-bromo-2-pyridylmethylthio)ethylamino]-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone, m.p. 105°-7°.

Workup

  1. temperaturewas heated
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-158be557d4d645f88d8671721789409e
Source dataset
uspto-grants-1980_10
Patent number
US04227000

Reaction notes

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