5-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidone → HCID 20279286, compound

HRID 903375Notes

Reaction equation

HRID 903375 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]2[C:11](=[O:20])[NH:12][C:13]([NH:16][N+]([O-])=[O:18])=[N:14][CH:15]=2)[CH:5]=[N:6][C:7]=1[CH3:8].[CH3:21][O:22][C:23]1[C:24]([CH2:29][CH2:30][CH2:31][CH2:32]N)=[N:25][CH:26]=[CH:27][CH:28]=1>C(O)C>[OH2:18].[OH2:22].[CH3:21][O:22][C:23]1[C:24]([CH2:29][CH2:30][CH2:31][CH2:32][NH:16][C:13]2[NH:12][C:11](=[O:20])[C:10]([CH2:9][C:4]3[CH:5]=[N:6][C:7]([CH3:8])=[C:2]([CH3:1])[CH:3]=3)=[CH:15][N:14]=2)=[N:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 127838315-(5,6-Dimethyl-3-pyridylmethyl)-2-nitroamino4-pyrimidoneHCID 130600284-(3-Methoxypyridin-2-yl)butan-1-amine

Product 1

HCID 20279286HCID 20279286, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Equimolar amounts of 5-(5,6-dimethyl-3-pyridylmethyl)-2-nitroamino-4-pyrimidone and 4-(3-methoxy-2-pyridyl)butylamine were heated together under reflux in ethanol for 24 hours. An additional 0.1 molar equivalent of the amine was added and the mixture was heated under reflux for a further 24 hours, evaporated to dryness and purified to give 2-[4-(3-methoxy-2-pyridyl)butylamino]-5-(5,6-dimethyl-3-pyridylmethyl)-4-pyrimidone dihydrate, m.p. 93°-94°.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for a further 24 hours
  3. customevaporated to dryness
  4. custompurified

Sources & evidence

ORD record
ord-8a9e3dd4f4fa48b6bc730d2d22263871
Source dataset
uspto-grants-1980_10
Patent number
US04227000

Reaction notes

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