HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone → 2-[2-(2-Thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone | HCID 12783832 | — |
| Reactant | 2-[(Thiazol-2-yl)methylthio]ethylamine | HCID 12923403 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-[2-(2-Thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone | HCID 12799559 | 60% |
Reaction Steps
An equimolar mixture of 2-nitroamino-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone and 2-(2-thiazolylmethylthio)ethylamine was heated under reflux in ethanol for 18 hours. The solid which crystallised out on cooling was recrystallised from ethanol to give 2-[2-(2-thiazolylmethylthio)ethylamino]-5-(6-methoxy-3-pyridylmethyl)-4-pyrimidone, m.p. 95°-7°, in 60% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04227000 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-1e7d6139b95f407699e0c0f8c9a38676 |
| Source note | uspto-grants-1980_10 |