HRID903455

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID24408

Bromine

Br2

HCID145742

L-Proline

C5H9NO2

HCID289763

4-(3,4-dichlorophenyl)-4-oxobutanoic acid

C10H8Cl2O3

结构：O=C(CCC(=O)N1CCC[C@H]1C(=O)O)c1ccc(Cl)c(Cl)c1

HCID53782556

1-[4-(3,4-Dichlorophenyl)-1,4-dioxobutyl]-L-proline

C15H15Cl2NO4

PRODUCTS

生成物

结构：O=C(c1ccc(Cl)c(Cl)c1)C(Br)CC(=O)N1CCC[C@H]1C(=O)O

HCID54412937

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

The preceding compound is heated with 6 N hydrochloric acid to give 3-(3,4-dichlorobenzoyl)propionic acid. As described in Example 15, 3-(3,4-dichlorobenzoyl)propionic acid, hydroxysuccinimide ester is prepared and coupled to L-proline as in Example 16. The 1-[3-(3,4-dichlorobenzoyl)propionyl]-L-proline in acetic acid is reacted with bromine as in Example 20 to give 1-[3-bromo-3-(3,4-dichlorobenzoyl)propionyl]-L-proline.

WORKUP

后处理

customis prepared