HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → 1-[3-bromo-3-(3,4-dichlorobenzoyl)propionyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 4-(3,4-Dichlorophenyl)-4-oxobutyric acid | HCID 289763 | — |
| Reactant | 1-[3-(3,4-dichlorobenzoyl)propionyl]-L-proline | HCID 53782556 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-[3-bromo-3-(3,4-dichlorobenzoyl)propionyl]-L-proline | HCID 54412937 | — |
Reaction Steps
The preceding compound is heated with 6 N hydrochloric acid to give 3-(3,4-dichlorobenzoyl)propionic acid. As described in Example 15, 3-(3,4-dichlorobenzoyl)propionic acid, hydroxysuccinimide ester is prepared and coupled to L-proline as in Example 16. The 1-[3-(3,4-dichlorobenzoyl)propionyl]-L-proline in acetic acid is reacted with bromine as in Example 20 to give 1-[3-bromo-3-(3,4-dichlorobenzoyl)propionyl]-L-proline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226775 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-eb42c77cd8a14aacac1ee69226cb38fd |
| Source note | uspto-grants-1980_10 |