HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthalenecarboxaldehyde → HCID 53995490, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthalenecarboxaldehyde | HCID 6201 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 2-methyl-4-(naphthalen-2-yl)-4-oxobutanoic acid | HCID 293040 | — |
| Reactant | HCID 23700354 | HCID 23700354 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 53995490 | HCID 53995490 | — |
Reaction Steps
As for Example 48, 2-naphthaldehyde is converted to 3-(2-naphthoyl)-2-methylpropionic acid and coupled to L-proline. The 1-[3-(2-naphthoyl)-2-methylpropionyl]-L-proline is separated into isomers A and B. Isomer A, (S)-1-[3-(2-naphthoyl)-2-methylpropionyl]-L-proline is reacted with bromine in acetic acid and the product reacted with sodium thioacetate in acetonitrile as for Example 72 to give the product of the example as a glass (mixture of diastereomers).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226775 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-d450547e158e4ff1bd57ca8be40adfd7 |
| Source note | uspto-grants-1980_10 |