HRID903552

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3283

Diethyl Ether

C4H10O

$结构：CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O$

HCID5280363

Dinoprost

C20H34O5

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：CCCCC[C@H](O)/C=C/[C@@H]1[C@@H](CCCCCCC(=O)O)[C@@H](O)C[C@H]1O

HCID5280939

(9alpha,11alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid

C20H36O5

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Refer to Chart 36. The mixed formula-CC bis(THP ether) of the PGF2α compounds (Example 36, 1.5 g.) in 60 ml. of ethyl acetate are reduced at C5 -C6 by hydrogenation at about 25° C. in the presence of 200 mg. of 5% palladium-on-carbon with slightly over the theory for one equivalent of hydrogen. The solids are filtered off and the filtrate concentrated to yield the corresponding formula-CCXII bis(THP ether) of the PGF1α compounds having Rf 0.28 (TLC on silica gel in acetone-Skellysolve B (1:2)).

WORKUP

后处理

filtrationThe solids are filtered off
concentrationthe filtrate concentrated