HCID 45586, compound → HCID 23336469, compound

HRID 903587Notes

Reaction equation

HRID 903587 reaction equation
[CH2:1]([NH:5][CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3].[CH3:17][O:18][C:19]([CH2:21][CH2:22][CH2:23][C:24](Cl)=O)=[O:20]>>[CH2:1]([N:5]([CH2:24][CH2:23][CH2:22][CH2:21][C:19]([O:18][CH3:17])=[O:20])[CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 45586HCID 45586, compoundHCID 73916Methyl 4-chloroformylbutyrate

Product 1

HCID 23336469HCID 23336469, compoundYield 73.5%

Procedure

10 g of N-isobutyl-tryptamine (i.e., 3-(2-isobutylaminoethyl)-indole) and 9.1 g of 4-methoxycarbonylbutyryl chloride were treated in the same manner as described in Example 1. 11.23 g of N-isobutyl-N-(4-methoxycarbonylbutyl)-tryptamine (i.e., 3-[2-(N-isobutyl-4-methoxycarbonylbutanamido)ethyl]-indole) were thereby obtained. Yield: 70.5%

Sources & evidence

ORD record
ord-f4874ceb878344fa8a4ce3824dd947b3
Source dataset
uspto-grants-1980_10
Patent number
US04228168

Reaction notes

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