Hydrochloric Acid → HCID 23336504, compound

Participants

Reaction Conditions

Reaction Steps

2 ml of methanol, 2 ml of conc. hydrochloric acid and 10 ml of 10% hydrochloric acid were added to 0.7 g of 1,2,3,4-tetrahydro-1-[3,3-bis(ethoxycarbonyl)propyl]-2-ethyl-β-carboline, and the mixture was stirred at 120° C. for 7 hours. After the reaction was completed, the mixture was evaporated under reduced pressure to remove solvent. The residue thus obtained was recrystallized from a mixture of ethanol and ether. 0.49 g of 1,2,3,4-tetrahydro-1-(3-carboxypropyl)-2-ethyl-β-carboline hydrochloride was obtained. M.p. 194°-197° C. (decomp.) Yield: 73.5%

Provenance & Evidence