Hydrochloric Acid → HCID 23336504, compound

HRID 903599Notes

Reaction equation

HRID 903599 reaction equation
[ClH:1].C([O:4][C:5]([CH:7](C(OCC)=O)[CH2:8][CH2:9][CH:10]1[C:22]2[NH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]=2[CH2:13][CH2:12][N:11]1[CH2:23][CH3:24])=[O:6])C>CO>[ClH:1].[C:5]([CH2:7][CH2:8][CH2:9][CH:10]1[C:22]2[NH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:14]=2[CH2:13][CH2:12][N:11]1[CH2:23][CH3:24])([OH:6])=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 23336464HCID 23336464, compound

Product 1

HCID 23336504HCID 23336504, compoundYield 73.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
120 °C

Procedure

2 ml of methanol, 2 ml of conc. hydrochloric acid and 10 ml of 10% hydrochloric acid were added to 0.7 g of 1,2,3,4-tetrahydro-1-[3,3-bis(ethoxycarbonyl)propyl]-2-ethyl-β-carboline, and the mixture was stirred at 120° C. for 7 hours. After the reaction was completed, the mixture was evaporated under reduced pressure to remove solvent. The residue thus obtained was recrystallized from a mixture of ethanol and ether. 0.49 g of 1,2,3,4-tetrahydro-1-(3-carboxypropyl)-2-ethyl-β-carboline hydrochloride was obtained. M.p. 194°-197° C. (decomp.) Yield: 73.5%

Workup

  1. customthe mixture was evaporated under reduced pressure
  2. customto remove solvent
  3. customThe residue thus obtained
  4. customwas recrystallized from a mixture of ethanol and ether

Sources & evidence

ORD record
ord-be09702889724237b2fc3d9a51656c87
Source dataset
uspto-grants-1980_10
Patent number
US04228168

Reaction notes

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