Pyridine → HCID 70586823, compound

HRID 903621Notes

Reaction equation

HRID 903621 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:22][CH2:21][C@@:12]34[C:13]5[CH:14]=[C:15]([OH:20])[CH:16]=[CH:17][C:18]=5[CH2:19][C@@H:6]2[C@:7]3([OH:23])[CH2:8][CH2:9][O:10][CH2:11]4)[CH2:3][CH2:2]1.[C:24](Cl)(=[O:26])[CH3:25].N1C=CC=CC=1>C(Cl)Cl>[C:24]([O:20][C:15]1[CH:16]=[CH:17][C:18]2[CH2:19][C@H:6]3[N:5]([CH2:4][CH:1]4[CH2:2][CH2:3]4)[CH2:22][CH2:21][C@@:12]4([C:13]=2[CH:14]=1)[C@@:7]3([OH:23])[CH2:8][CH2:9][O:10][CH2:11]4)(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 57212445HCID 57212445, compound

Product 1

HCID 70586823HCID 70586823, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Equimolar quantities of 17-cyclopropylmethyl-3,14β-dihydroxy-6-oxamorphinan (XVI), acetyl chloride and pyridine are mixed together in dry methylene chloride and the resultant mixture is heated at reflux for several hours to produce the title compound.

Workup

  1. temperatureat reflux for several hours

Sources & evidence

ORD record
ord-d89301602678468abc6235a1dd6a76b9
Source dataset
uspto-grants-1980_10
Patent number
US04228285

Reaction notes

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