Pyridine → HCID 70582839, compound

HRID 903622Notes

Reaction equation

HRID 903622 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:22][CH2:21][C@@:12]34[C:13]5[CH:14]=[C:15]([OH:20])[CH:16]=[CH:17][C:18]=5[CH2:19][C@@H:6]2[C@:7]3([OH:23])[CH2:8][CH2:9][O:10][CH2:11]4)[CH2:3][CH2:2]1.Cl.[C:25](Cl)(=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[N:28][CH:27]=1.N1C=CC=CC=1>C(Cl)Cl>[CH:1]1([CH2:4][N:5]2[CH2:22][CH2:21][C@@:12]34[C:13]5[CH:14]=[C:15]([O:20][C:25](=[O:32])[C:26]6[CH:31]=[CH:30][CH:29]=[N:28][CH:27]=6)[CH:16]=[CH:17][C:18]=5[CH2:19][C@@H:6]2[C@:7]3([OH:23])[CH2:8][CH2:9][O:10][CH2:11]4)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 1049PyridineHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 57212445HCID 57212445, compound

Product 1

HCID 70582839HCID 70582839, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Equimolar amounts of 17-cyclopropylmethyl-3,14β-dihydroxy-6-oxamorphinan (XVI), nicotinoyl chloride hydrochloride and pyridine are mixed together in dry methylene chloride and the mixture is heated at reflux for 3 hours to produce the title compound.

Workup

  1. temperaturethe mixture is heated
  2. temperatureat reflux for 3 hours

Sources & evidence

ORD record
ord-85f2ce482bcf4c7284e23cad7fb05f71
Source dataset
uspto-grants-1980_10
Patent number
US04228285

Reaction notes

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