HRID903719

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1117

Sulfate

O4S-2

HCID2794575

pyridazin-3-ylmethanol

C5H6N2O

结构：O=[N+]([O-])c1cc([N+](=O)[O-])c([O-])c([N+](=O)[O-])c1

HCID4432340

Picrate anion

C6H2N3O7-

HCID20242505

未命名化合物

PRODUCTS

生成物

结构：NCCSCc1cccnn1.O=[N+]([O-])c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1.O=[N+]([O-])c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1

HCID86737273

未命名化合物

HCID178513026

未命名化合物

PROCEDURE

实验过程

By the procedure of Example 1, using 3-hydroxymethylpyridazine, the intermediate 3-[(2-aminoethyl)thiomethyl]pyridazine dipicrate, m.p. 145°-148° is prepared. Converting this picrate to the dihydrobromide, then to the free base by the procedure of Example 1 and reacting the 3-[(2-aminoethyl)thiomethyl]pyridazine with S-methylsiothiouronium sulphate by the procedure of Example 1 gives the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fc36eafd42d14dd386759eccec607015
来源数据集: uspto-grants-1980_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04228291
来源说明: uspto-grants-1980_10

反应 SMILES

OCC1N=[N:5][CH:6]=CC=1.[C:9]1([C:23]([O-:24])=[C:19]([N+:20]([O-:22])=[O:21])[CH:18]=[C:14]([N+:15]([O-:17])=[O:16])[CH:13]=1)[N+:10]([O-:12])=[O:11].[NH2:25][CH2:26][CH2:27][S:28][CH2:29][C:30]1[N:31]=[N:32][CH:33]=[CH:34][CH:35]=1.[S:36]([O-:40])([O-:39])(=[O:38])=[O:37]>>[C:19]1([C:23]([OH:24])=[C:9]([N+:10]([O-:12])=[O:11])[CH:13]=[C:14]([N+:15]([O-:17])=[O:16])[CH:18]=1)[N+:20]([O-:22])=[O:21].[C:19]1([C:23]([OH:24])=[C:9]([N+:10]([O-:12])=[O:11])[CH:13]=[C:14]([N+:15]([O-:17])=[O:16])[CH:18]=1)[N+:20]([O-:22])=[O:21].[NH2:25][CH2:26][CH2:27][S:28][CH2:29][C:30]1[N:31]=[N:32][CH:33]=[CH:34][CH:35]=1.[S:36]([OH:40])([OH:39])(=[O:38])=[O:37].[N:32]1[CH:33]=[CH:34][CH:35]=[C:30]([CH2:29][S:28][CH2:27][CH2:26][NH:25][C:6]([NH2:5])=[NH:10])[N:31]=1