N-3-Bromopropylphthalimide → 3-(3-Aminopropylamino)-1,2,4-thiadiazole

HRID 903778Notes

Reaction equation

HRID 903778 reaction equation
[NH2:1][C:2]1[N:6]=[CH:5][S:4][N:3]=1.C1(=O)[N:11](CCCBr)[C:10](=O)[C:9]2=CC=CC=[C:8]12>>[NH2:11][CH2:10][CH2:9][CH2:8][NH:1][C:2]1[N:6]=[CH:5][S:4][N:3]=1

Participants

3

Reactant 2

HCID 21611N-3-BromopropylphthalimideHCID 202496641,2,4-Thiadiazol-3-amine

Product 1

HCID 205576553-(3-Aminopropylamino)-1,2,4-thiadiazole

Procedure

Reaction of 3-amino-1,2,4-thiadiazole with 3-phthalimidopropyl bromide and hydrazinolysis of the product gives 3-(3-aminopropylamino)-1,2,4-thiadiazole and from this intermediate N-cyano-N'-methyl-N"-[3-(3-(1,2,4-thiadiazolyl)amino)propyl]-guanidine is prepared.

Sources & evidence

ORD record
ord-ce2a51f12e3945078ac3869bd89562fc
Source dataset
uspto-grants-1980_10
Patent number
US04228291

Reaction notes

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